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The officials said Saturday that the drone attack in the central province of Bayda killed 5 Somalis and a Yemeni.
Fighters linked to Al-Qaida in the Arabian Peninsula briefly overran parts of Bayda earlier this year.
The officials say that further south in Abyan province, fighting between Yemeni troops and al-Qaida fighters that broke out late Friday and continued into Saturday 12 soldiers and 22 al-Qaida militants.
The officials say the clashes took place some 10 kilometers (six miles) outside Jaar, a key town that has been under the control of militants since last year.
The officials spoke on condition of anonymity in line with military regulations.